Best Cream For Painful Knees in 2022

There are a lot of different creams on the market that claim to be the best for painful knees. But how do you know which one is actually going to work? We’ve done the research for you and found that the best cream for painful knees is the Penetrex Pain Relief Cream.

This cream has been clinically proven to reduce pain and inflammation in the knees, and it’s also been shown to improve mobility and range of motion. It contains a unique blend of ingredients that are known to be effective at relieving pain, and it’s non-greasy and easy to apply.

If you’re looking for a pain relief cream that actually works, we highly recommend the Penetrex Pain Relief Cream.

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Things to Consider:

Before you buy a cream for your painful knees, there are a few things you should consider. First, what is the cause of your knee pain? If you don’t know, it’s a good idea to see a doctor to find out. Once you know the cause, you can choose a cream that’s specifically designed to treat that type of pain.

Second, what are the ingredients in the cream? Make sure to read the label carefully and avoid anything that you’re allergic to. You also want to make sure the cream won’t further irritate your skin.

Third, how long will you need to use the cream? If you only need it for a short-term fix, you might not need to spend as much money on a high-quality cream. However, if you’re looking for long-term relief, it’s worth it to spend a little extra on a cream that will last.

Finally, ask your doctor or pharmacist for recommendations. They can help you narrow down your options and choose the best cream for your needs.

How We Pick & Test:

There’s a lot of creams on the market that claim to help with knee pain, but how can you know which one is best? We’ve done the research to help you find the most effective cream for your painful knees.

We started by looking at the ingredients in each cream. We looked for creams that contained active ingredients like Arnica, Boswellia, or Capsaicin. These ingredients have been shown to be effective at reducing pain and inflammation.

We then looked at how each cream was tested. We only considered creams that had been clinically tested on humans, not animals. We also looked for creams that had been tested by unbiased third-party labs.

Finally, we looked at customer reviews. We only considered creams that had mostly positive reviews from customers who reported relief from their knee pain.

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Based on our research, we believe that the best cream for painful knees is the amara organic Arnicacream. This cream contains Arnica, Boswellia, and Capsaicin, all of which are proven to be effective at reducing pain and inflammation. The cream has also been clinically tested on humans and has been given a seal of approval by the National Athletic Trainers’ Association.

Top 10 Best Cream For Painful Knees

Details of Best Cream For Painful Knees

SaleBestseller No. 1
Penetrex Joint & Muscle Therapy – 2oz Cream – Intensive Concentrate for Joint and Muscle Recovery, Premium Formula with Arnica, Vitamin B6 and MSM Provides Relief for Back, Neck, Hands, Feet
  • A different kind of joint & muscle relief: Penetrex is the whole-body therapy cream you’ve been waiting for. Trusted by over 2 million loyal users, Penetrex offers remarkably effective relief.
  • Revolutionary Delivery System: Our proprietary blend of natural ingredients leverages a uniquely powerful synergy of arnica, vitamin B6 and MSM to penetrate deeply, diminishing joint and muscle discomfort at its source.
  • The premium experience in muscle recovery: This ultra-soothing remedy is a non-greasy, non-sticky, non-staining—and cruelty-free—vegan solution to joint and muscle pain without the burn, freeze or strong odor of most relief products.
  • Discover why so many people trust and rely on Penetrex: This alternative pain relief cream enables you to get back to the activities you love, without the limitations of joint and muscle discomfort.
  • Directions: Apply to back, neck, knee, hand, foot, and other pain points. Can be used as a potent solo treatment or partnered with heating pads, ice packs, muscle massagers and supplements. Apply 3-4 times per day for 7-10 days, then as needed.
SaleBestseller No. 2
Arthritis Pain Relief Cream, Amish Origins Maximum Strength Deep Penetrating Relieving for Aches, Neuropathy, Joint, Muscle, Back, Knee, Feet, Hand, Ankle, Restless Legs, Shoulder
  • PROVIDES FAST RELIEF FROM PAIN: Carefully formulated with active ingredients that target pains, Amish Origins Deep Penetrating Pain Relief Cream is formulated to provide long-lasting relief from pains associated with Arthritis, aching joints, sore muscles, restless legs, bruises, sprains, backache and more.
  • QUICK-ACTING PAIN RELIEF FORMULA: Amish Origin medicated pain relief cream has earned its reputation as one of the best on the market, and that’s because it delivers on its promises. As a powerful pain relief cream, Amish Origins pain relief cream absorbs quickly and delivers fast relief from pain.
  • GREASELESS FORMULA: While other pain relief formula leave behind annoying greasy residues after application, Not Amish Origins. This is because Amish Origins is carefully formulated to deeply penetrate the skin without the greasy feel.
  • EASY TO USE: This pain relief cream is easy to use. Simply apply a little amount topically, wherever you feel pain, and watch the magic unfolds.
  • SPECIALLY FORMULATED: to provide quick, therapeutic, and deep soothing relief from pain, Amish Origins Deep Penetrating Pain Relief Cream is perfect for treating aching joints, restless legs, bruises, arthritis, headache, muscle strains, backache, sprains and more.
SaleBestseller No. 3
Boiron Arnicare Gel for Soothing Relief of Joint Pain, Muscle Pain, Muscle Soreness, and Swelling from Bruises or Injury - Non-greasy and Fragrance-Free - 2.6 oz
  • ARNICA FOR PAIN: This homeopathic medicine helps temporarily relieve muscle pain & stiffness due to minor injuries, overexertion & falls. Also great for pain, swelling, & discoloration from bruises.
  • TOPICAL PAIN RELIEF: Our non-greasy, water-based formula absorbs quickly & is unscented & paraben-free. This cooling gel is great for relief following an injury, intense workout, or general overexertion.
  • PLANT-BASED ACTIVE INGREDIENT: The Arnica montana plant is a natural pain reliever. This popular homeopathic medicine temporarily relieves muscle pain & stiffness without unwanted drowsiness.Fluoride-Free
  • HOMEOPATHIC MEDICINE uses highly diluted biological, botanical, or mineral substances to relieve symptoms. Our tablets, pellets, & topical treatments work with your body without the risk of contraindications, or known drug interactions.
  • THE BOIRON PROMISE: We believe there’s more than one way to feel better. Since 1932, we have been committed to providing quality medicines. As a world leader in homeopathy, our passion is your health. Our promise is your satisfaction.
SaleBestseller No. 4
Vita Sciences Advanced Neuropathy Support, Peripheral Neuropathy & Fibromyalgia Pain Relief Cream | All Natural Nerve Pain Treatment | Nervex | Vita Sciences
  • Neuropathy Pain Relief Cream and natural way to provide topical vitamins and nutrients with measured doses from our airless dispenser.
  • Odor -Free, Scientifically established to work.
  • Nervex contains high doses of Vitamin B12 and Vitamin E. This advanced formula also includes: Vitamin B1, B5, & B6, Capsaicin, MSM, Cetyl Myristoleate, and Andrographis extract that all work to lessen symptoms and support synapse repair.
  • Moisturizers and antioxidants allow this powerful cream to easily absorb into the skin.
  • Delivers 30 applications of lotion in protected and measured amounts, Natural ingredients assure this lotion is gentle to your skin.
SaleBestseller No. 5
MagniLife Pain Relieving Foot Cream, All-Natural Moisturizing Foot Pain Relief with Beeswax and Eucalyptus to Soothe Soreness, Burning, Tingling, and Sensitivity - 4oz
  • NATURAL PAIN RELIEF - A pain-relieving topical cream for shooting, stabbing, burning, and tingling pain. Intense moisturizing treatment soothes severely dry, cracked, itchy, and sensitive skin. Relief is here for those experiencing soreness, aches, pain or suffering from burning discomfort. Give yourself the relief you deserve, so you can get back to doing the things you love or need to do.
  • ALL-NATURAL INGREDIENTS - Naturally derived, intense moisturizing cream soothes severely dry, cracked, itchy, and sensitive skin with gelsemium, beeswax, cudweeds, bergamot, camphor and eucalyptus. Our deep penetrating, non-greasy formula contains active ingredients to help deliver fast-acting, serious relief when you need it most.
  • NOTHING ADDED BUT THE GOOD STUFF - Free from mineral oils, petroleum, fragrance and dyes, making it suitable for people with diabetes and 100% safe to use between toes. Our moisturizing cream is also safe to use on legs and hands for a quick soothing massage.
  • SAFE, PLANT-DERIVED TOPICAL - A great benefit of our cream is it does not interfere with other medications. A safe option for someone who is currently taking medication or wants to avoid medicines that can be harsh on the body.
  • TRUSTED BRAND WITH YOU IN MIND - MagniLife has been a trusted business for over 20 years. All of our products are developed and manufactured in our state-of-the art facilities. Made with highly qualified formulators to ensure excellence in quality and consistency, we ensure top quality products and are dedicated to providing products that help to improve quality of life. Start your journey to a healthy lifestyle today!
SaleBestseller No. 6
Urea Cream 40% Plus Salicylic Acid 4.6 Oz, Callus Remover Hand Cream Foot Cream For Dry Cracked Feet, Hands, Heels, Elbows, Nails, Knees, Intensive Moisturizes & Softens Skin, Exfoliates Dead Skin
  • INTENSIVE MOISTURIZING CREAM FOR DRY, CRACKED, ROUGH AND BUMPY SKIN - This highest potency Urea Cream 40% for feet, hands, elbows, nails intensively and quickly moisturizes, softens and smooths thick, callused, scaling skin
  • GENTLY EXFOLIATES SCALES & DEAD SKIN, RESTORES SKIN BARRIER - Infused with 2% Salicylic Acid to purify and exfoliate the skin, and combined with intensive urea 40% to improve cellular turnover, this dry skin cream repairs and heals the skin to achieve healthy, pain-free and baby-soft skin
  • SOFTENS THICK, CRACKED SKIN, RELIEVES DRY, ITCHY SKIN - Enriched with Tea Tree Oil, Aloe Vera, Coconut Oil, Camellia Green Tea Leaf Extract, this foot hand repair cream reduces redness, inflammation and irritation
  • MINIMIZES CORNS & CALLUSES, REDUCES CALLUS BUILDUP - This cracked heel treatment foot cream rehydrates and nourishes dry cracked skin, removes dead skin to help get rid of corns and calluses
  • MADE IN USA! ADVANCED ULTRA REPAIR CREAM FOR FEET, HEELS, HANDS, ELBOWS, NAILS, AND KNEES - This cracked skin repair cream is Odor-Free and ideal for ALL skin types. Formulated & bottled in the USA! Never tested on animals - Cruelty-Free & Vegan-Friendly! cGMP Certified, Hypoallergenic, Paraben-Free, Sulfate-Free
SaleBestseller No. 7
Hemp Cream by New Age - Help Relieve Discomfort in Knees, Joints, and Lower Back - Natural Hemp Extract Cream - Made in USA - 2 Pack
  • Hemp Cream by New Age is created using a powerful blend of Hemp, Arnica oils and other natural ingredients to give it that extra punch and effectiveness you need. Non-sticky and non-greasy, leaving you with an awesome fresh feeling and a pleasant natural scent on your skin!
  • Deep Penetrating Formula - This fast-absorbing formula moisturizes skin while penetrating deep into the epidermis promoting a soothing effect on muscle and joint discomfort supporting relaxed state.
  • All Natural Ingredients - Extra Strength Hemp Cream is one of nature’s abundant sources of Omega-3 and Omega-6. Both healthy fatty acids have moisturizing properties that help the skin stay healthy
  • Instant Acting Formula - Hemp Cream extract has been found to soothe swollen and tender joints. Relieves Neck, Hip, Shoulder, Muscle, Joint, Elbow, Back
  • Grown & Made in America - We are proud that our all-natural hemp oils are made in a certified and inspected lab, so you can trust in us and the product you are buying; NEW AGE has high professional quality standards - every single batch of NEW AGE product is third-party tested, and each bottle is manufactured here in the United States.
SaleBestseller No. 8
Aspercreme Maximum Strength Pain Relief Cream with Aloe, 5 oz, for Arthritis, Joint & Muscle Pain
  • Contains one (1) 5-oz. tube of Aspercreme Odor Free Maximum Strength Pain Relief Cream for Arthritis, Joint & Muscle Pain
  • Max Strength Pain Relief: The active ingredient in this topical pain cream is clinically proven for minor arthritis, joint and muscle pain
  • Odor-free Pain Cream: Max strength Aspercreme has no odor for discreet pain relief when you need it most
  • Non-greasy Formula: Aspercreme Pain Relief Creme is made with soothing aloe and won't leave a greasy residue
  • Easy-open Tube: Odor-free Aspercreme comes in an easy-to-open flip top cap for fast, effective pain relief
Bestseller No. 9
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief, No Prescription Needed - 3.5 oz/100 g Tubes (Pack of 2)
  • Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief
  • Number 1 Doctor Recommended topical pain relief brand
  • Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
  • An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management
  • Diclofenac Sodium Topical Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain rather than just masking it
SaleBestseller No. 10
Neuropathy Nerve & Pain Relief Cream – Maximum Strength Pain Cream for Feet, Hands, Legs, Toes Includes Arnica, Vitamin B6, Aloe Vera, MSM - Scientifically Developed for Effective Relief 2oz
  • Strong & Potent Formula – Fortified with our concentrated blend of Arnica, Vitamin B6, MSM, Aloe Vera, and Vitamin E, Pharmapulse’s Maximum Strength Neuropathy cream helps nourish and support targeted areas of discomfort for long lasting relief.
  • Calming Support – With consistent application, our cream is designed to provide deep soothing relief for your back, neck, knees, hips, shoulders, elbows, joints, and muscles.
  • Cooling & Strengthening Complex – Each jar of our premium quality cream is made with natural and safe ingredients to deliver you with powerful cooling and intense rejuvenation, while providing essential moisturizing benefits to all skin types.
  • Crafted With Pride – Made in Canada from hand-picked ingredients, each jar is produced in small batches to meet our highest quality standards. Our unique cream is non-greasy and lightweight, which means you don't need much balm to get maximum, lasting relief.
  • Our Commitment to Every Customer – At Pharmapulse, our mission to provide you with high-quality, authentic products and the best customer care. Each purchase is backed by our 100% satisfaction guarantee. If you require assistance with our product, feel free to contact us with any questions or concerns.

Benefits of Best Cream For Painful Knees:

The benefits of using the best cream for painful knees are its ability to reduce swelling and inflammation. It also helps to support the joints and muscles around the knee. Additionally, the cream can also help to reduce the pain associated with arthritis.

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There is no definitive answer to this question as everyone’s pain tolerance threshold is different. However, many people find that topical creams with a moderate amount of menthol are effective at numbing pain without being overly irritating. As always, it is important to test a small amount of cream on a small area of skin before applying it to a larger area.


There is no one-size-fits-all answer to the question of what is the best cream for painful knees. However, there are some basic principles that should be followed when choosing a cream for this purpose. First, the cream should be designed to meet the specific needs of the individual. Second, the cream should be easy to apply and be comfortable to wear. Third, the cream should be able to provide relief from pain and swelling. Finally, the cream should be safe for use on the knees.

Ease of Use:

The best cream for painful knees should be easy to apply and have a smooth texture. It should also be easy to remove and not leave any residue.


There are plenty of good creams out there for painful knees, but what makes the best cream for painful knees so convenient? Well, for one thing, you don’t have to worry about applying it to your knee every day. Just put some on before you go to bed, and you’ll be good to go in the morning. Plus, the best cream for painful knees will usually have a wide variety of uses. So, if you start to experience pain in other areas of your body, you can likely still use the cream to help ease the discomfort.


There are a number of factors to consider when purchasing a cream for painful knees. The first is durability. You want to make sure the cream can withstand repeated use and still provide the same level of relief. The second is the price. You don’t want to spend a fortune on a cream that may not work. The third is the ingredients. You want to make sure the cream contains ingredients that are known to be effective in relieving pain.

Frequently Ask Questions:

How can cream relieve pain?

Cream provides a layer of protection over the skin and can help to soothe and relax muscles. It can also increase blood flow to the area, which can help to reduce inflammation and pain.


There is no one-size-fits-all answer to this question, as the best cream for painful knees will vary depending on the individual’s specific needs. However, some general tips that may help include: seeking out a cream that contains anti-inflammatory ingredients such as Arnica or Boswellia, applying the cream directly to the affected area, and massaging the cream into the skin.

Last update on 2022-10-06 / Affiliate links / Images from Amazon Product Advertising API.

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